Matilda Clark
Profile
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Dr. Matilda Clark |
Curriculum Vitae (Short Version)
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02.2025 + Postdoctoral Scientist Otto-von-Guericke University, Biocatalysis
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10.2020 – 09.2024 PhD in Biology, University of Portsmouth
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Doctoral Thesis: Characterisation of Enzymes for Industrial Biorecycling of Polyesters
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Supervisor: Professor Andrew Pickford
Co-supervisors: Dr John McGeehan, Dr Victoria Bemmer
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09/2016 – 06.2020 Bachelor of Science, University of Leicester, Biochemistry
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Bachelor’s Thesis: Structural Biology in Drug Discovery and Development
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Supervisor: Professor Mark Carr
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Research
In the research group of Professor Jan von Langermann, I study biocatalytic reactions with the focus on process-optimization including modifying reaction conditions.
My focus is on the sustainable production and recycling of plastics. I am working on biocatalytic methods for the depolymerisation of polymers such as poly(ethylene furanoate) and nylon. This has advantages over current recycling methods such as the use of mild conditions and the ability to create a circular plastic economy.
I am also working on the enzymatic synthesis of plastics such as polyhydroxyalkanoates and polycarbonates. These reactions can use renewable resources to create biodegradable plastics with a variety of different properties.
If you are looking for a place for an internship or a thesis in the field of biochemistry (biocatalysis) and biotechnology, or if you have any questions, suggestions or just want to get in touch, please do not hesitate to contact me. I am always happy and open to new input and collaborations.
Scientific Papers
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Groseclose, T.M., Kober, E.A., Clark, M. Moore, B., Ramesh, K.J., Taylor, Z.K, Lujan, L.A, Beckham, G.T., Pickford, A.R., Dale, T.T., Nguyen, H.B. Engineering PHL7 for improved poly(ethylene terephthalate) depolymerization via rational design and directed evolution
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Groseclose, T,M., Kober, E.A., Clark, M. Moore, B., Banerjee, S., Beckham, G.T., Pickford, A.R., Dale, T.T., Nguyen, H.B. A high-throughput screening platform for engineering poly(ethylene terephthalate) (PET) hydrolases
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Clark, M., Tornesakis, K., König, G., Zahn, M., Lichtenstein, B.R., Pickford, A.R. and Cox, P.A. Understanding the Catalytic Efficiency of Two Polyester Degrading Enzymes: An Experimental and Theoretical Investigation
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Avilan, L., Lichtenstein, B.R., König, G., Zahn, M., Allen, M.D., Oliveira, L., Clark, M., Bemmer, V., Graham, R., Austin, H.P. and Dominick, G., 2023. Concentration‐dependent inhibition of mesophilic PETases on poly (ethylene terephthalate) can be eliminated by enzyme engineering